What Is PDRN? Bielenda PDRN 150 vs Hyaluronic Spicule

PDRN serum explained: Bielenda PDRN vs hyaluronic biomicroneedle serum

2026-10-08

Bielenda Skin Clinic Professional PDRN 150 and Hyaluronic 100 bio-microneedle spicule serums

Key takeaways

PDRN is one of the most searched skincare ingredients right now. On the ingredient list of this Bielenda PDRN serum, it appears as "DNA".
The "microneedles" here are not needles. They are hydrolysed sponge spicules from natural freshwater sponge, and they give a mild tingling sensation.
If you want fresher-looking skin and care about fine lines, choose PDRN 150. If your skin is very dry and dehydrated, choose Hyaluronic 100.
Use in the evening on the face only, avoiding the eye area. Do not combine with exfoliants, AHA/BHA acids, retinol or vitamin C during use.

What is PDRN and what does it do?

PDRN (polydeoxyribonucleotide) is an ingredient made up of DNA fragments. The ingredient list of Bielenda Skin Clinic Professional PDRN serum shows it as "DNA".

Bielenda describes PDRN as a revitalising and nourishing ingredient. The serum also contains neuropeptides and adenosine: neuropeptides target the look of fine lines and skin firmness, while adenosine helps with elasticity and gives skin a more radiant look. Niacinamide also appears on the ingredient list. According to Bielenda, skin feels smoother and more revitalised after one use; after a month, fine lines look smoother and skin feels firmer and more even.

PDRN products are often called "salmon serums". However, Bielenda does not state the source of the DNA in this serum, so we do not describe it as salmon-derived. Simply check the ingredients and directions when choosing.

What are bio-microneedles?

There is no need to worry about the word "microneedle". These two serums need no device and contain no needles. Bielenda uses hydrolysed sponge spicules from natural freshwater sponge: 150,000 per bottle in the PDRN serum and 100,000 per bottle in the hyaluronic serum.

Bielenda explains that the spicules stimulate the skin and help active ingredients penetrate, so a mild tingling sensation is normal.

PDRN 150 vs Hyaluronic 100: which one is right for you?

Bielenda Skin Clinic Professional PDRN Bio-Microneedle Serum 150, Revitalising and Nourishing, 30ml

Best for: tired, dull skin; concerns about fine lines and firmness
Key ingredients: PDRN (listed as DNA), neuropeptides, adenosine, 150,000 sponge spicules
Brand-stated results: smoother, more revitalised skin after one use; smoother fine lines and firmer, more even skin after one month
Use: in the evening, in a 14 to 28-day course

Shop Bielenda PDRN 150 Bio-Microneedle Serum →

Bielenda Skin Clinic Professional Hyaluronic Bio-Microneedle Serum 100, Stimulating and Moisturising, 30ml

Best for: very dry, dehydrated or rough-feeling skin (Bielenda says it is especially suited to very dry skin)
Key ingredients: low-molecular hyaluronic acid, polyglutamic acid (PGA), beta-glucan, 100,000 sponge spicules
Brand-stated results: more hydrated skin after one use; firmer, smoother skin with less visible wrinkles after one month
Use: in the evening, in a 14 to 28-day course

Shop Bielenda Hyaluronic 100 Bio-Microneedle Serum →

In short: choose PDRN to revitalise, and hyaluronic to hydrate. If you want to try both, finish one course before switching to the other, so it is easier to see how your skin responds.

How to use bio-microneedle serums

In the evening after cleansing, apply evenly to the face, avoiding the eye area, and let it absorb completely. Follow with a moisturiser if needed.
Bielenda recommends a 14 to 28-day course for both serums.
You may feel tingling, slight burning, warmth, tightness or mild redness. This usually fades quickly and is a normal reaction to the spicules. Stop using if any other discomfort occurs.
Bielenda advises not to combine with exfoliants, AHA/BHA acids, retinol or vitamin C during use, and not to use straight after aesthetic medicine treatments.
Do not use on damaged or irritated skin, and avoid contact with the eyes and mucous membranes.
Both serums contain fragrance. If you are sensitive to fragrance, test behind your ear or along your jawline first.
Wear sunscreen during the day while using these serums.

How do these compare with other PDRN products?

Our PDRN products come in different formats. These two Bielenda serums are 30ml evening serums, ideal for a nightly course at home.

If you prefer single-use PDRN ampoules, we also carry Mastelli Placentex PDRN 5.625mg (5 x 3ml), applied topically and used up straight after opening. The two are used differently, so check each product page for directions and precautions before buying.

FAQ

Can I use PDRN serum every night?

Yes. Bielenda recommends using it in the evening in a 14 to 28-day course. Pause retinol, vitamin C, AHA/BHA acids and exfoliants during the course.

Is the tingling normal?

Yes. Sponge spicules cause mild tingling, and you may also feel warmth or see mild redness, which usually fades quickly. Stop using if tingling persists or other discomfort occurs.

Can I use microneedle serums around the eyes or on the neck?

Do not use around the eyes. Bielenda's directions are for the face only, avoiding the eye area.

Can I use them after aesthetic treatments?

Bielenda advises not to use these serums straight after aesthetic medicine treatments.

Are they suitable for sensitive skin?

Do not use on damaged or currently irritated skin. Both serums contain fragrance, so sensitive skin should patch test behind the ear or along the jawline first.